Introduction to the adsorbent Kremezin
- H.Kitaoka
- Sep 17
- 4 min read
Updated: Sep 19

To patients taking Kremezin
Introduction
Chronic kidney disease (CKD) is a disease that many people suffer from in Japan. The kidneys are also known as the silent organ, as symptoms are hard to detect, and by the time you notice it, the disease is often already advanced. When kidney function declines, unnecessary waste products accumulate in the body, causing various effects on the entire body."Kremezin" is a medication used for patients with chronic kidney disease, and plays a major role in protecting the kidneys and maintaining quality of life. This booklet explains in as easy-to-understand a manner as possible how Kremezin works, how to take it, precautions, and lifestyle tips.
Kidney function and chronic kidney disease
The kidneys are organs located around the waist, one on each side, that filter blood to produce urine and excrete waste products, excess water, and salt from the body. They also have many other important functions, such as regulating blood pressure, secreting hormones, and supporting the production of red blood cells.
However, a disease in which kidney function declines chronically is called "chronic kidney disease." Causes include high blood pressure, diabetes, aging, and nephritis. When kidney function declines, substances called "uremic toxins," which would normally be excreted in urine, accumulate in the body, causing symptoms such as loss of appetite, nausea, fatigue, itching, and anemia.
As the condition progresses, dialysis may become necessary, but continued use of Kremezin can help delay the need for dialysis.
Characteristics and effects of Kremezin
Kremezin is a type of medicine called an "oral adsorbent." Its ingredients have porous charcoal-like properties, and it adsorbs uremic toxins in the intestines and excretes them with the feces.
In other words, even if the kidneys cannot process waste products sufficiently, the intestines can remove toxins in advance, which reduces uremic toxins in the blood and reduces the burden on the kidneys.
Clinical studies have shown that taking Kremezin can slow the deterioration of kidney function, and is particularly expected to play a role in preventing the progression to kidney failure.
Directions
Usually taken three times a day after mealsFollow the instructions of your doctor or pharmacist.
The medicineWithout chewing, rinse with water or lukewarm waterIf you chew it, black powder will spread in your mouth and may turn your teeth or tongue black.
Taking this medicine with other medicines may weaken its effectiveness.Take Kremezin and other medications 1 to 2 hours apartThe basic rule is to do this.
If you miss a dose, take it as soon as you remember. However, if it is almost time for your next dose, do not take two doses at once, but only take one dose.
Side effects and countermeasures
1. Constipation
This is the most common side effect. Because adsorbents act in the intestines, stool tends to become hard.
Stay hydrated
Eat lots of vegetables and fiber
Get enough exerciseIf this doesn't improve the condition, consult a doctor and consider using a laxative.
2. Black teeth, tongue, and stool
This is due to the ingredients in the food, and is not harmful to the body. Brushing your teeth and gargling can help prevent this to some extent.
3. Loss of appetite and nausea
This rarely occurs when the medicine remains in the intestines. If you experience severe symptoms, consult your doctor.
4. Intestinal obstruction (ileus)
This is a rare but serious side effect. If you experience symptoms such as severe abdominal bloating or pain, nausea, or difficulty passing stool, see a doctor immediately.
The importance of continuing to take medication
Kremezin is not a medicine that will make you feel better immediately after taking it. The effects appear slowly, so it is most important to continue taking it every day without fail. If you stop taking it midway, your kidney function may deteriorate and you may need dialysis sooner.
Don't think, "I don't have any symptoms, so I don't need to take it," but follow your doctor's instructions and continue taking it for a long time, which will help protect your quality of life.
Tips for everyday life
Lifestyle is also very important to get the most out of your medication.
meal: The basic rule is to limit salt intake. Processed foods and restaurant meals contain a lot of salt, so be careful. You may need to limit your protein, potassium, and phosphorus intake, so consult a registered dietitian or doctor for advice.
moisture: Depending on your kidney condition, you may need to limit your intake of fluids. Follow your doctor's instructions. To prevent constipation, be sure to drink only as much fluid as permitted.
sportsLight exercise helps maintain healthy kidneys and the heart. It's important to continue moderate exercise, such as walking or stretching, within your limits.
Regular inspections: Check kidney function with blood and urine tests and check the effectiveness and side effects of the medication.
summary
Kremezin is an important medication that helps support the kidneys and delays dialysis as much as possible. It is important to take it every day while being careful of side effects.
By incorporating changes to your own lifestyle, you can increase the effectiveness of your medication and lead a more comfortable daily life. If you have any questions or concerns, please feel free to consult your doctor or pharmacist.



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