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The world's first tape preparation for allergic rhinitis <ALLESAGA Tapes>


Hisamitsu Pharmaceutical ALLESAGA Tape

The tape formulation as a treatment for allergic rhinitis is an interesting product that has not been approved outside Japan.


Feature of ALLESAGA Tapes

This drug is a transdermal preparation containing emedastin fumarate (trade name: Remicut capsule, etc.) as an active ingredient, and is the world's first tape preparation for the treatment of allergic rhinitis. Since it is a transdermal preparation, it can be safely used for patients with impaired swallowing ability and patients at risk of aspiration, and the medication status can be visually confirmed by family members and caregivers.


Adherence can be expected to improve because there are no restrictions on the timing of administration depending on the diet.


Allergic rhinitis is a type I allergic disease with sneezing, runny nose, and nasal congestion as the main symptoms. Asthma is often present at the same time, and both have been recognized as systemic inflammatory diseases in recent years. Antihistamines are widely used as drug treatments for allergic rhinitis.


Among them, second-generation antihistamines including this drug are the disease type in mild cases in the treatment of perennial allergic rhinitis. Regardless, it is listed as a first-line drug for swelling and rhinitis in moderate cases, and nasal spray steroids and second-generation antihistamines for severe cases of swelling and rhinitis. It is supposed to be used together.


Also, in the treatment of seasonal allergic rhinitis (hay fever), the use of second-generation antihistamines is widely recommended depending on the severity and type of disease.

In Japan, the only dosage form of histamine is oral, nasal drops, or injections. You can expect a 24-hour effect by applying it once a day.


Hisamitsu Pharmaceutical Aresaga Tape


Mechanism of action

ALLESAGA tapes is classified as a second-generation antihistamine (second-generation H1 receptor antagonist) and has both an inhibitory effect on the release of chemical mediators from mast cells due to an allergic reaction and an antihistamine effect.


[Usage / Dose]

In general, for adults, apply 4 mg of emedastin fumarate once to the chest, upper arm, back or abdomen, and replace it every 24 hours. The dose can be increased to 8 mg depending on the symptoms.


[Side effects]

In Japanese clinical studies, adverse reactions were observed in 201 of 1,060 patients (19.0%). The main adverse reactions were application site erythema in 116 cases (10.9%), pruritus in 48 cases (4.5%), application site papules in 21 cases (2.0%) and drowsiness in 52 cases (4.9%).


Precautions for use

・ Since side effects of medicines are likely to occur in patients with hepatic dysfunction, it is necessary to carefully apply the drug while observing the patient's condition. (Careful administration)


・ When using this drug for seasonal patients, it is desirable to start using it immediately before the onset season and continue until the end of the onset season.


・ Since ALLESAGA tapes is reapplied every day, please consider the time such as bathing when instructing the application start time.


・ It is a tape that is applied once a day.


・ Do not operate dangerous machinery such as driving a car while using this medicine as it may cause drowsiness.


・ Avoid breastfeeding.


・ Alcoholic beverages may increase side effects such as drowsiness, so avoid drinking alcohol while applying this drug.


・ Do not open the packaging bag until you use this product, and attach it immediately after opening. Please use by peeling off the liner.


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