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Drugs used for irritable bowel syndrome (IBS)

woman with stomach pain

Drugs that regulate the contents of the intestinal tract and functions of the intestinal tract are used as pharmacotherapy for IBS.

The following drugs are commonly used and used together for irritable bowel syndrome (IBS)

Polifyful・Colonel (Polymer polymer)

By absorbing a large amount of water and forming a gel, the stool contains an appropriate amount of water and increases the volume of the stool. (Image of disposable diapers)

It is highly safe and is positioned as a basic therapeutic drug for both constipation and diarrhea.

bloating and abdominal pain may be observed.

abdominalIt has the effect of activating peristalsis in the intestinal tract and suppressing increased peristalsis.

is said to be effective for constipation, diarrhea, and alternating types.

It is said to work suppressively, and is effective in preventing sudden pain, with almost no side effects.

Irribow(Serotonin receptor (5-HT3 receptor) antagonist) <Not available as a prescription drug.medicine

promotes activation of intestinal peristalsis and improvement of abnormal intestinal water transport, suppresses diarrhea, and improves stool shape and defecation urgency.

It also has the effect of improving visceral hypersensitivity such as abdominal pain and abdominal discomfort.


Suppresses the activation of intestinal motility and is suitable for cases with severe abdominal pain Not suitable for constipation Contraindicated in patients with prostatic hyperplasia or glaucoma with high intraocular pressure.


Other are not recommended for IBS

GASMOTIN (Mosapride Citrate)

5-HT4 receptor stimulant

constipation It is said to be effective and is recommended in guidelines.


Currently, various laxatives are prescribed, but stimulant laxatives are not recommended for long-term use.

There is a wealth of evidence for osmotic laxatives, with magnesium oxide being the mainstream and polyethylene glycol, but recently the PEG formulation Movicol (prescription drug) has become available in Japan.

AMITIZA, Linzeth, Goofys (mucosal epithelial function modifying drug) <Not available as a prescription drug. >

Increase the secretion of intestinal juice into the intestinal tract, soften the stool, enhance intestinal transport, and promote defecation., which has been reported to be effective for constipation types overseas and is recommended in guidelines,

was originally sold as a specific medicine for IBS-C, and may be effective if you complain of.

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